WebJun 5, 2024 · CB-1158 is an investigational immuno-oncology metabolic checkpoint inhibitor designed to target arginase, a critical immunosuppressive enzyme responsible for T-cell … WebCB-1158 (INCB01158) is an orally bioavailable, potent (IC50 = 98 nM), and selective (minimal off-target activity at 50000 nM) inhibitor of human arginase I, an immune-mediated anti-tumor agent. L-arginine is a critical metabolite for T-cell receptor signaling and subsequent T-cell proliferation, and depletion of arginine arrests T-cell growth.

CB-1158 (INCB01158) Phase I Solid Tumor Data Presented at the …

WebSOUTH SAN FRANCISCO, Calif., June 05, 2024 (GLOBE NEWSWIRE) -- Calithera Biosciences, Inc. (Nasdaq:CALA), a clinical stage biotechnology company focused on the development of novel cancer therapeutics, announced that clinical data from its product candidate CB-1158, a first-in-class arginase inhibitor, will be presented in an oral presentation at the American… WebCB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in … howell\u0027s auto repair

Calithera Announces First Patient Treated in Phase I Cohort of ...

WebNumidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, … WebARG inhibitor INCB01158 was administered twice daily beginning from week 3 post MM induction. ( A ) Proliferation histograms. ( B ) Percentage of proliferating OT-I T cells in control (healthy C57BL/6 mice transferred with OT-I T cells and immunized with OVA protein) and MM-bearing mice treated were indicated with ARG inhibitor INCB01158. WebCB-1158 (INCB01158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent. Product information CAS Number: 2095732-06-0 Molecular Weight: 287.12 Formula: C11H22BN3O5 howell\\u0027s auto diesel repair