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Dysfunctional State of T Cells or Exhaustion During Chronic Viral ...

WebOct 8, 2015 · Areas of limited statehood where the state is absent or dysfunctional are rarely ungoverned or ungovernable spaces. The provision of rules and regulations, as well as of public goods and services – governance – does not necessarily depend on the existence of functioning state institutions. WebThis activated T-cell response can inflict an overwhelming degree of damage to the targeted cells, which in most instances leads to the control and elimination of foreign invaders. However, in conditions of chronic infection, persistent exposure of T cells to high levels of antigen results in a severe T-cell dysfunctional state called exhaustion. WebThis review sheds light on the dysfunctional state of T cells during chronic viral infection … dwork roth book