Atf6a kda
WebATF6 is originally a 90 kDa type II transmembrane glycoprotein that is converted to a 50 kDa soluble nuclear form, retaining its N-terminal domain, including the leucine zipper. … WebSep 22, 2016 · Previous Page Table of Contents Download the Guidebook Next Page Types of Forms Processing ATF Form 6A ATF F 5330.3C (ATF E Form 6A) — Release and …
Atf6a kda
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WebFeb 21, 2024 · Lastly, ATF6a is an ER transmembrane protein. Upon accumulation of misfolded proteins in the ER, ATF6a is released from GRP78 and translocates to the Golgi apparatus, where it is cleaved sequentially by site-1- and site-2-proteases. WebAntibodies (Ab) against BIP (78 kDa), ATF6 (90 kDa), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and horseradish peroxidase (HRP)-conjugated goat anti-rabbit secondary Ab were purchased from Proteintech, Wuhan, China. Phosphorylated PERK (p-PERK; Thr 981, 125 kDa) Ab was purchased from Santa Cruz Biotechnology, Santa …
WebMay 25, 2024 · Indeed, ATF6α is a potent transcriptional activator whereas ATF6β, a poor transcriptional activator, may inhibit activation by ATF6α [ 7 ]. In contrast with the protein kinases PERK and IRE1 (type I transmembrane proteins), ATF6α is a 90 kDa type II transmembrane glycoprotein and member of the bZIP transcription factor family [ 8 ]. Web221 rows · (6) Cleaved 60 and 36 kDa ATF6 forms have also been described in the …
WebFC experiment of HeLa using 24169-1-AP. 1X10^6 HeLa cells were intracellularly stained with 0.4 ug Anti-Human ATF6 (24169-1-AP) and CoraLite®488-Conjugated AffiniPure … WebFeb 15, 2016 · When overexpressed, ATF6 and ATF6a intensify chondrogenesis; our studies demonstrate that under the stimulation of ATF6 and ATF6a, chondrocytes tend …
WebJun 1, 2015 · ATF6 is a member of the ATF/CREB (cAMP response element–binding protein) family of basic leucine-zipper (bZIP) transcription factors encoded by two paralogs, ATF6 and ATF6B. ATF6A is a key...
WebThe basic domain of ATF6 functions as a nuclear localization signal and the basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. painted cooler designsWebSection I - Importation Information (Use a separate ATF Form 6A (5330.3C) to describe articles imported under each permit.Also, use a separate form for each shipment under … painted cookies wilton ctWebMar 21, 2024 · GeneCards Summary for ATF6 Gene. ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include Achromatopsia 7 … HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with … XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with … SERPINE1 (Serpin Family E Member 1) is a Protein Coding gene. Diseases … FCGR3A (Fc Gamma Receptor IIIa) is a Protein Coding gene. Diseases … EPCAM (Epithelial Cell Adhesion Molecule) is a Protein Coding gene. Diseases … MPZ (Myelin Protein Zero) is a Protein Coding gene. Diseases associated with … SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator … HEXA (Hexosaminidase Subunit Alpha) is a Protein Coding gene. Diseases … IGFBP7 (Insulin Like Growth Factor Binding Protein 7) is a Protein Coding gene. … EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases … painted cooler beachWebAll lanes : Anti-ATF6 antibody (ab83504) at 1 µg/ml Lane 1 : Wild-type HeLa cell lysate Lane 2 : ATF6 knockout HeLa cell lysate Lysates/proteins at 20 µg per lane. Performed under … subtitles the hangman 1959WebFeb 15, 2016 · ATF6a, Chondrocyte hypertrophy, UPR, Transcription factor, Regulation INTRODUCTION In eukaryotic cells, endoplasmic reticulum (ER) stress is known to initiate a signaling pathway called the unfolded protein response (UPR) ( Hetz, 2012; Zhang and Kaufman, 2004; Ron and Walter, 2007 ). subtitles the batmanWebSep 15, 2015 · BMP2 induces mild ER stress, and then ATF6, as a 90-kDa protein (p90ATF6) in previous non-ER stress environment, is directly converted to a 50-kDa protein (p50ATF6, ATF6a) in ER-stressed cells. As revealed in Fig. 1e, ATF6 undergoes proteolysis and splicing after BMP2 stimulation. painted cooler master cosmos 2WebJun 17, 2024 · ATF6α in unstressed cells exists as a mixture of disulfide-linked oligomers and monomers. Upon stress, the interchain and intrachain disulfides are reduced giving rise to the suggestion that only the reduced monomeric form … painted cooler ideas for guys